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Updated: Jul 9, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
Published on: February 16, 2016
Noninvasive cardiac imaging with computed tomography
Gregory T Wilson1, Prabhakaran Gopalakrishnan, Tahir Tak
1Department of Internal Medicine, Plaza Medical Center of Fort Worth, Fort Worth, Texas, USA..
Insights
Multislice CT angiography (MSCT) offers a noninvasive method for evaluating heart disease, surpassing older CT techniques. While limitations exist, MSCT is a valuable tool for cardiac pathology assessment.
Area of Science:
- Cardiology
- Medical Imaging
- Radiology
Background:
- Heart disease remains a leading cause of global morbidity and mortality.
- Invasive coronary angiography is the current gold standard for diagnosing obstructive coronary artery disease.
- Advancements in cardiac CT offer noninvasive alternatives for evaluating cardiac conditions.
Purpose of the Study:
- To review the role and advancements of multislice CT angiography (MSCT) in cardiac imaging.
- To discuss the capabilities of MSCT beyond diagnosing obstructive coronary artery disease.
- To highlight the limitations and future directions of MSCT in clinical practice.
Main Methods:
- Review of current literature on CT techniques for cardiac evaluation.
- Comparison of multislice CT angiography (MSCT) with traditional methods like invasive coronary angiography and electron beam CT.
- Discussion of MSCT's application in visualizing coronary artery disease and other cardiac abnormalities.
Main Results:
- Multislice CT angiography (MSCT) provides accurate, noninvasive characterization of atherosclerotic coronary disease.
- MSCT offers detailed multidimensional visualization of cardiac structures, largely replacing coronary artery calcium scoring.
- MSCT's applications are expanding to include congenital defects, thoracic procedure planning, and cardiac function assessment.
Conclusions:
- MSCT is an increasingly valuable tool for noninvasive cardiac pathology evaluation.
- Despite limitations in patients with arrhythmias, stents, or calcified coronaries, MSCT accuracy is improving.
- Further research is needed to define the optimal incorporation of MSCT/CT angiography into clinical practice.
Abstract:
Despite major improvements in the treatment of heart disease, it remains a major source of morbidity and mortality on a global scale. Currently, invasive coronary angiography remains the gold standard for identification of obstructive coronary artery disease. However, recent advances in computerized tomographic (CT) techniques of the heart allow for accurate, noninvasive characterization of atherosclerotic coronary disease and other cardiac abnormalities. The calculation of coronary artery calcium scores with electron beam CT has largely been supplanted by high-resolution CT angiography using multislice detectors (MSCT) which can provide detailed multidimensional visualization of cardiac structures. Although evaluation of obstructive coronary disease is the primary use of MSCT, its use in identifying congenital defects, planning thoracic procedures and characterizing cardiac function continues to grow. Accordingly, appropriate incorporation of MSCT/CT angiography into clinical practice continues to be defined. Several limitations to MSCT remain which reduce its accuracy, such as in patients with arrhythmia and in patients with either coronary stents or heavily calcified coronaries. Despite its current limitations, MSCT remains a rapidly advancing field and an increasingly valuable tool for the noninvasive evaluation of cardiac pathology.
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