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Related Experiment Video

Updated: Jul 9, 2026

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

Nonpathological senescence arises from unsuitable external influences.

Alexander V Khalyavkin¹, Anatoli I Yashin

¹Institute of Biochemical Physics of RAS, 4 Kosygin St, Moscow 119334, Russia. ab3711@mail.sitek.net

Annals of the New York Academy of Sciences

|December 7, 2007

Summary

Environmental factors significantly influence aging. Modulating external stimuli can decelerate, halt, or even reverse aging, potentially extending lifespan by optimizing organismal renewal processes.

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Techniques to Induce and Quantify Cellular Senescence

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

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Last Updated: Jul 9, 2026

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

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Published on: August 12, 2018

Techniques to Induce and Quantify Cellular Senescence

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

Area of Science:

Biogerontology
Environmental Science
Cellular Biology

Background:

Aging is influenced by environmental factors.
External stimuli can ameliorate and rejuvenate biological entities.
Nonpathological cellular aging may be reversible and caused by external signals.

Purpose of the Study:

To investigate environmental control over the rate of aging in whole organisms.
To explore the concept of an 'ageless' state under specific natural conditions.
To understand how environmental conditions affect aging and lifespan.

Main Methods:

Theoretical extension of cellular aging principles to whole organisms.
Analysis of the trade-offs between environmental mortality and aging in different conditions.
Hypothesizing the impact of mild versus stimulating environments on renewal processes.

Main Results:

A specific range of natural conditions may allow organisms to remain 'ageless'.
Milder environments can lead to incomplete renewal and aging.
Reduced environmental mortality can initially compensate for age-dependent mortality, increasing life expectancy.

Conclusions:

Environmental conditions play a crucial role in regulating aging.
Manipulating environmental stimuli can decelerate, stop, or reverse aging.
Optimizing environmental factors can significantly extend mean and extreme lifespan.