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Jaundice

Jaundice

Jaundice, or icterus, is the yellow discoloration of the skin, sclerae, and mucous membranes. It happens when plasma bilirubin levels rise above 2.5-3 mg/dL, leading to bilirubin deposition in tissue.Bilirubin is a byproduct of hemoglobin degradation. In macrophages, hemoglobin breaks down into globin and heme. Globin is converted into amino acids, while heme is turned into biliverdin by heme oxygenase, which is then reduced to unconjugated bilirubin by biliverdin reductase.Unconjugated...

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Related Experiment Video

Updated: Jul 9, 2026

Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates

Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates

Published on: August 23, 2022

Neonatal hyperbilirubinemia: an unexpected cause.

Nidhy S Paulose¹, David Hart, Daniel Rauch

¹Baylor College of Medicine, Pulmonary Medicine, Texas Children's Hospital, Houston, Texas, USA. nspaulos@texaschildrenshospital.org

Clinical Pediatrics

|December 7, 2007

Summary

Neonatal hyperbilirubinemia can signal serious conditions like hemophilia A. Early evaluation of anemia and bleeding in newborns is crucial for diagnosing inherited coagulation disorders.

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Isolation of Neonatal Extrahepatic Cholangiocytes

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Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates

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Isolation of Neonatal Extrahepatic Cholangiocytes

Isolation of Neonatal Extrahepatic Cholangiocytes

Published on: June 5, 2014

Area of Science:

Neonatal Medicine
Pediatric Hematology
Clinical Case Study

Background:

Hyperbilirubinemia is a frequent reason for neonatal hospital admissions.
While often benign, it necessitates a broad differential diagnosis.
Atypical symptoms like anemia or bleeding warrant investigation for underlying disorders.

Observation:

A 5-day-old infant presented with hyperbilirubinemia, anemia, and ecchymoses.
Symptoms were attributed to birth trauma.
The infant required hospitalization for management.

Findings:

The case highlights hemophilia A as a potential cause of neonatal hyperbilirubinemia with anemia and bleeding.
Diagnostic evaluation and management protocols for hemophilia A are reviewed.
This condition requires careful consideration in the differential diagnosis of neonatal jaundice.

Implications:

Recognizing atypical signs in neonatal hyperbilirubinemia is vital for timely diagnosis of rare conditions.
Prompt identification and management of inherited coagulation defects can prevent severe complications.
This case underscores the importance of a comprehensive approach to neonatal jaundice.