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Related Experiment Video

Updated: Jul 9, 2026

Orthotopic Liver Transplantation in Rats
18:25

Orthotopic Liver Transplantation in Rats

Published on: July 1, 2012

Liver transplantation: an update.

R C Verdonk1, A P van den Berg, M J H Slooff

  • 1Department of Gastroenterology & Hepatology, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands. r.c.verdonk@int.umcg.nl

The Netherlands Journal of Medicine
|December 7, 2007
PubMed
Summary

Liver transplantation is a successful treatment for end-stage liver disease, with improving survival rates and expanding indications. Ongoing challenges include donor organ shortages and managing long-term recipient health.

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Area of Science:

  • Hepatology
  • Transplant Surgery
  • Immunology

Background:

  • Liver transplantation has been a standard treatment for end-stage liver disease since the 1980s.
  • Significant advancements have improved care for liver transplant candidates and recipients.
  • Current one- and five-year patient survival rates are approximately 85% and 75%, respectively.

Purpose of the Study:

  • To provide a comprehensive update on recent developments in liver transplantation.
  • To highlight progress in patient care, recipient selection, and long-term management.
  • To address challenges such as donor organ scarcity and evolving indications.

Main Methods:

  • Review of recent literature and clinical practice in liver transplantation.
  • Analysis of trends in patient survival, indications, and contraindications.

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Last Updated: Jul 9, 2026

Orthotopic Liver Transplantation in Rats
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Orthotopic Liver Transplantation in Rats

Published on: July 1, 2012

Vascular Reconstruction with the Cuff Technique in Mouse Orthotopic Liver Transplantation
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Vascular Reconstruction with the Cuff Technique in Mouse Orthotopic Liver Transplantation

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Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
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Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model

Published on: August 17, 2022

  • Discussion of innovations in perioperative care and long-term follow-up strategies.

    • Main Results:

    • Indications for liver transplantation are broadening, with decreasing contraindications.
    • The Model for End-Stage Liver Disease (MELD) score is a key tool for recipient selection.
    • Perioperative care is highly standardized, with reduced blood loss during procedures.
    • Long-term care focuses on managing recurrent diseases, de novo malignancies, and cardiovascular conditions.

    Conclusions:

    • Liver transplantation is a highly successful therapy with improving outcomes.
    • Addressing donor organ shortages and optimizing long-term recipient health are critical.
    • The goal is to achieve normal life expectancy and quality of life for transplant recipients.