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[Quality evaluation of magnesium oxide tablets using acid neutralization test and dissolution test].
Chiaki Inoue1, Toshiaki Kogure, Aya Kamata
1Department of Pharmacy, The Hospital of Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya City 6633-8501, Japan. ykinochi@hyo-med.ac.jp
Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan
|December 7, 2007
Summary
Commercial magnesium oxide (MgO) tablets vary in acid neutralization. Effective MgO tablets require a dissolution rate exceeding 81.1% for significant acid neutralization, as demonstrated by comparative tablet testing.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Context:
- Commercially available magnesium oxide (MgO) tablets are widely used for acid neutralization.
- Quality evaluation of these tablets necessitates understanding their dissolution and acid neutralization properties.
Purpose:
- To evaluate the acid neutralization and dissolution behaviors of commercially available magnesium oxide (MgO) tablets.
- To establish a benchmark dissolution rate for effective acid neutralization.
Summary:
- Two types of MgO tablets, Magmit and Maglax, were tested for acid neutralization in simulated gastric fluid (pH 1.2).
- Magmit exhibited a rapid dissolution rate (81.1% in 20 min) and raised the pH to 8.9.
- Maglax showed a slower dissolution rate (77.1% in 60 min) and a final pH of 2.5.
Impact:
- The study indicates that a dissolution rate greater than 81.1% is crucial for MgO tablets to achieve significant acid neutralization.
- Findings provide a quality control standard for magnesium oxide antacid formulations.
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