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Related Experiment Video

Updated: Jul 9, 2026

Multiplex Detection of Bacteria in Complex Clinical and Environmental Samples using Oligonucleotide-coupled Fluorescent Microspheres

Multiplex Detection of Bacteria in Complex Clinical and Environmental Samples using Oligonucleotide-coupled Fluorescent Microspheres

Published on: October 23, 2011

A universal combination treatment for vaginitis.

Jacob Bornstein¹, Doron Zarfati

¹Department of Obstetrics and Gynecology, Western Galilee Hospital, Nahariya, Israel. mdjacob@gmail.com

Gynecologic and Obstetric Investigation

|December 7, 2007

Summary

A new vaginal tablet combining clotrimazole and metronidazole (Clo-Met) effectively treats Candida vaginitis. Further research is needed to evaluate Clo-Met for bacterial vaginosis and Trichomonas vaginalis infections.

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Protocols for Vaginal Inoculation and Sample Collection in the Experimental Mouse Model of Candida vaginitis

Protocols for Vaginal Inoculation and Sample Collection in the Experimental Mouse Model of Candida vaginitis

Published on: December 8, 2011

Area of Science:

Gynecology
Infectious Diseases
Pharmacology

Background:

Vaginitis is a common gynecological condition often caused by Candida albicans, bacterial vaginosis, or Trichomonas vaginalis.
Current treatments exist, but novel therapeutic approaches are continually being investigated for improved efficacy and broader coverage.

Purpose of the Study:

To compare the efficacy of a novel vaginal tablet containing clotrimazole and metronidazole (Clo-Met) against a clotrimazole-only tablet.
To assess the therapeutic effectiveness of the combined therapy in treating various forms of vaginitis.

Main Methods:

A multicenter, double-blind, randomized controlled study was conducted.
165 women diagnosed with vaginitis (Candida, bacterial vaginosis, T. vaginalis, or combinations) and without recent treatment were enrolled.
Participants were assigned to either the combined Clo-Met tablet or the clotrimazole-only tablet group.

Main Results:

The study enrolled 165 patients, with 84 in the Clo-Met group and 81 in the clotrimazole group.
The combined clotrimazole and metronidazole (Clo-Met) tablet demonstrated significantly higher effectiveness in treating Candida vaginitis compared to clotrimazole alone (p < 0.012 and p < 0.05).

Conclusions:

The combination vaginal tablet of clotrimazole and metronidazole (Clo-Met) is therapeutically effective for candidal vaginitis.
Further investigation is warranted to determine the effectiveness of Clo-Met in treating bacterial vaginosis, T. vaginalis infections, and mixed microbial vaginal infections.