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[Resistance of Streptococcus pneumoniae in Galicia]
M L Pérez del Molino1, J M López, M T Garea
1Servicio de Microbiología, Hospital General de Galicia, Santiago de Compostela.
Abstract:
We studied the antibiotic sensitivity of 130 Streptococcus pneumonia strains isolated from respiratory samples (96 cases), blood (13 cases), CSF (6 cases), ocular secretions (5 cases) and other origins (10 cases). High-level penicillin-resistance was found in 13.08% of strains, and intermediate-level penicillin resistance was also found in 22.3% of strains. A multiple-antibiotic resistance pattern was shown by 80.44% of all penicillin-resistant strains. Resistance rates found against antibiotics were as follows: tetracycline, 41.53%; chloramphenicol 17.69%; cotrimoxazole, 16.92% and erythromycin 6.92%. All isolated strains were sensitive to rifampin and vancomycin.
Insights
This study found high rates of antibiotic resistance in Streptococcus pneumoniae strains, with over 80% of penicillin-resistant strains showing multiple-drug resistance. However, all strains remained sensitive to rifampin and vancomycin.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Streptococcus pneumoniae is a leading cause of bacterial infections worldwide.
- Antibiotic resistance in S. pneumoniae poses a significant public health threat.
- Understanding local resistance patterns is crucial for effective treatment.
Purpose of the Study:
- To determine the antibiotic sensitivity profiles of Streptococcus pneumoniae strains.
- To assess the prevalence of penicillin resistance and multiple-drug resistance.
- To identify effective antibiotics against isolated strains.
Main Methods:
- Analysis of 130 Streptococcus pneumoniae strains from various clinical samples.
- Testing antibiotic sensitivity against common antimicrobial agents.
- Evaluation of penicillin resistance (high-level and intermediate-level).
Main Results:
- High-level penicillin resistance observed in 13.08% and intermediate resistance in 22.3% of strains.
- 80.44% of penicillin-resistant strains exhibited multiple-antibiotic resistance.
- Resistance rates: tetracycline (41.53%), chloramphenicol (17.69%), cotrimoxazole (16.92%), erythromycin (6.92%).
- All strains were sensitive to rifampin and vancomycin.
Conclusions:
- Significant penicillin and multidrug resistance in S. pneumoniae strains.
- Tetracycline, chloramphenicol, cotrimoxazole, and erythromycin show considerable resistance.
- Rifampin and vancomycin remain effective treatment options against these isolates.