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Renal inflammatory myofibroblastic tumor - a new case report
Amelia Petrescu1, Gabriela Berdan, Ionela Hulea
1Department of Pathology, Prof. dr. Th. Burghele Hospital, Bucharest, Romania. etamy58@yahoo.com
Summary
Renal inflammatory pseudotumor is a rare benign kidney tumor that can mimic renal cell carcinoma. Accurate preoperative diagnosis is challenging due to similar clinical and imaging features, necessitating careful histopathological evaluation.
Area of Science:
- Uropathology
- Oncology
- Radiology
Background:
- Renal inflammatory pseudotumor (RIP) is an uncommon benign renal neoplasm.
- RIP can be misdiagnosed as renal cell carcinoma (RCC) due to overlapping clinical and imaging features.
- Accurate diagnosis is crucial for appropriate patient management.
Observation:
- A 57-year-old male presented with hematuria, fever, and flank pain.
- MRI and sonography revealed a 2.5 cm mediorenal mass.
- The patient underwent nephroureterectomy, initially diagnosed as suspected RCC.
Findings:
- Macroscopic examination showed a 2 cm yellowish, gelatinous mass.
- Histopathology revealed spindle cell proliferation with lymphocytic infiltration and focal bone formation.
- Immunohistochemistry showed spindle cells positive for vimentin, actin, and CD68, and negative for markers of malignancy (desmin, HMB45, etc.).
Implications:
- This case highlights the diagnostic challenges of RIP, especially differentiating it from RCC preoperatively.
- Histopathological and immunohistochemical analysis are essential for definitive diagnosis.
- Awareness of RIP is important for clinicians and pathologists to avoid misdiagnosis and ensure correct treatment strategies.