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Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping
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fMRI reliability in subjects with stroke.

Teresa Jacobson Kimberley1, Gauri Khandekar, Michael Borich

  • 1Department of Physical Medicine and Rehabilitation Program in Physical Therapy/Rehabilitation Science, University of Minnesota, MMC 388, 426 Church St. SE, Minneapolis, MN 55455, USA. tjk@umn.edu

Experimental Brain Research
|December 7, 2007
PubMed
Summary
This summary is machine-generated.

Functional MRI (fMRI) shows good reliability for assessing brain changes in stroke survivors. This study confirms fMRI's utility in stroke rehabilitation research by validating its test-retest consistency.

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Area of Science:

  • Neuroimaging
  • Rehabilitation Medicine
  • Stroke Recovery

Background:

  • Functional MRI (fMRI) is crucial for evaluating brain changes post-stroke.
  • No prior systematic studies assessed fMRI signal reliability in stroke patients.

Purpose of the Study:

  • To systematically examine the within- and between-session reliability of fMRI signals.
  • To assess reliability in cortical and cerebellar regions during a visual-motor task in stroke subjects.

Main Methods:

  • Nine stroke subjects performed a continuous visual-motor task over four trials across two sessions (3 weeks apart).
  • Analyzed signal intensity change, active voxel count, and voxel-by-voxel statistics.
  • Reliability determined using Interclass Correlation Coefficients (ICC) in motor, sensory, premotor, and cerebellar regions.

Main Results:

  • Percent signal intensity change demonstrated superior reliability (Avg ICC: 0.73) compared to other methods.
  • Within-session reliability generally exceeded between-session reliability across all methods.
  • Moderate to good between-session reliability was observed for signal intensity change in key brain regions (e.g., PMC: 0.94, MCB: 0.86).

Conclusions:

  • fMRI exhibits good test-retest reliability in stroke patients performing a continuous motor task.
  • Findings support the use of fMRI for longitudinal research and clinical assessment in stroke populations.
  • Percent signal intensity change is a reliable metric for fMRI studies in stroke survivors.