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Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Cells and Tissue01:30

Bone Cells and Tissue

Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the periosteum and...

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Related Experiment Video

Updated: Jul 9, 2026

Osteoclast Derivation from Mouse Bone Marrow
06:17

Osteoclast Derivation from Mouse Bone Marrow

Published on: November 6, 2014

Functional grouping of osteoclast genes revealed through microarray analysis.

Guozhe Yang1, Mone Zaidi, Weijia Zhang

  • 1Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, NY 10029, USA.

Biochemical and Biophysical Research Communications
|December 7, 2007
PubMed
Summary

This study identifies key gene clusters involved in osteoclast differentiation. Understanding these gene modulations provides insights into osteoclast formation, function, and fate.

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Area of Science:

  • Molecular biology
  • Cell biology
  • Genomics

Background:

  • Osteoclasts are crucial for bone remodeling.
  • The molecular mechanisms driving osteoclast differentiation are complex and not fully understood.

Purpose of the Study:

  • To identify functional gene clusters modulated during osteoclast differentiation.
  • To explore the relevance of these gene clusters to osteoclast biology.

Main Methods:

  • Gene array analysis using Affymetrix chips.
  • RNA isolation from RAW264.7 cells stimulated with RANK-ligand for 5 days.
  • Pathway analysis of gene expression data.

Main Results:

  • Identification of distinct functional gene clusters upregulated and downregulated during osteoclastogenesis.
  • Some identified genes have known roles, while others represent novel targets.

Conclusions:

  • Functional gene clusters are significantly modulated during osteoclast differentiation.
  • These findings offer new perspectives on the genetic regulation of osteoclast formation, function, and fate.