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Updated: Jul 9, 2026
03:23
Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
Published on: May 10, 2024
Histopathologic features of eosinophilic esophagitis
1Department of Pathology, University of Cincinnati, Cincinnati, Ohio 45221, USA. margaret.collins@cchmc.org <margaret.collins@cchmc.org>
Gastrointestinal Endoscopy Clinics of North America
|December 7, 2007
Summary
Eosinophilic esophagitis (EE) has distinct esophageal histology, differing from normal tissue. Diagnosis requires correlating these findings with clinical symptoms for accurate identification.
Area of Science:
- Gastroenterology
- Pathology
- Immunology
Background:
- Eosinophilic esophagitis (EE) is an allergic inflammatory condition of the esophagus.
- Histological examination is crucial for diagnosing EE.
Purpose of the Study:
- To describe the characteristic histology of eosinophilic esophagitis (EE) in humans.
- To contrast EE histology with normal esophageal histology.
- To review relevant human and animal research on EE.
Main Methods:
- Histological analysis of esophageal biopsies.
- Comparison of pathological findings in EE versus normal esophagus.
- Literature review of human and animal studies.
Main Results:
- Fully developed eosinophilic esophagitis (EE) exhibits highly characteristic esophageal histology.
- Histologic alterations in EE are not specific to its cause.
- Normal esophageal histology is reviewed and contrasted with EE findings.
Conclusions:
- Accurate diagnosis of eosinophilic esophagitis (EE) depends on correlating characteristic histology with clinical findings.
- The illustrated findings aid in identifying EE.
- Further research in human and animal models is pertinent to understanding EE.
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