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Related Experiment Video

Updated: Jul 9, 2026

Single-Cell RNA Sequencing of Mutant Whole Mouse Embryos: From the Epiblast to the End of Gastrulation

Single-Cell RNA Sequencing of Mutant Whole Mouse Embryos: From the Epiblast to the End of Gastrulation

Published on: June 14, 2024

A transcriptome landscape of mouse embryogenesis.

Nicolas Fossat¹, Sabine Pfister, Patrick P L Tam

¹Embryology Unit, Children's Medical Research Institute, University of Sydney, Locked Bag 23, Wentworthville NSW 2145, Australia.

Developmental Cell

|December 7, 2007

Summary

This summary is machine-generated.

This study maps gene activity during mouse embryonic development, creating a resource to understand how gene expression shapes the body plan and organs. It reveals dynamic transcriptional changes critical for embryogenesis.

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Last Updated: Jul 9, 2026

Single-Cell RNA Sequencing of Mutant Whole Mouse Embryos: From the Epiblast to the End of Gastrulation

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Published on: June 14, 2024

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Area of Science:

Developmental Biology
Genomics
Transcriptomics

Background:

Embryonic development relies on precise genetic regulation for body plan formation and organogenesis.
Understanding the dynamic transcriptional landscape is crucial for deciphering developmental processes.

Discussion:

The study presents a chronological transcriptome series of postimplantation mouse embryos.
This resource captures genome-wide and gene-specific transcriptional dynamics during gastrulation and early organogenesis.

Key Insights:

Provides a detailed temporal map of gene expression during key embryonic stages.
Enables researchers to study the dynamic regulation of genes essential for development.

Outlook:

Facilitates future research into gene regulatory networks controlling embryogenesis.
Serves as a foundational dataset for comparative developmental studies.