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Isolation, Characterization, And High Throughput Extracellular Flux Analysis of Mouse Primary Renal Tubular Epithelial Cells
Published on: June 20, 2018
Equine renal tubular disorders.
Luis G Arroyo1, Henry R Stämpfli
1Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.
The Veterinary Clinics of North America. Equine Practice
|December 7, 2007
Summary
Renal tubular disorders in horses are rare, with only three types identified: nephrogenic diabetes insipidus and two forms of renal tubular acidosis (RTA). This review details these conditions.
Area of Science:
- Veterinary Medicine
- Nephrology
- Equine Health
Background:
- Renal tubular disorders are infrequently documented in equine populations.
- Three primary tubular defects are recognized in horses: nephrogenic diabetes insipidus, distal renal tubular acidosis (type I), and proximal renal tubular acidosis (type II).
Purpose of the Study:
- To review and consolidate information on renal tubular disorders in horses.
- To focus specifically on nephrogenic diabetes insipidus and the two types of renal tubular acidosis (RTA).
Main Methods:
- Literature review of reported equine renal tubular disorders.
- Synthesis of existing knowledge on the pathophysiology and clinical presentation of these conditions.
Main Results:
- Sporadic cases of renal tubular disorders have been reported in horses.
- The recognized defects include unresponsiveness to antidiuretic hormone (nephrogenic diabetes insipidus) and impaired acid-base balance (distal and proximal RTA).
Conclusions:
- Nephrogenic diabetes insipidus and renal tubular acidosis (types I and II) represent the known spectrum of equine renal tubular dysfunction.
- Further research may elucidate the incidence and underlying causes of these conditions in horses.
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