A flavonoid gossypin binds to cyclin-dependent kinase 2
Hojung Kim1, Eunjung Lee, Jihye Kim
1Department of Bioscience and Biotechnology, BMIC, 1 Hwayang-dong, Kwangjin-Ku, Konkuk University, Seoul 143-701, Republic of Korea.
Bioorganic & Medicinal Chemistry Letters
|December 8, 2007
Abstract:
Flavonoids have low toxicity and mild activity. In order to find flavonoids showing cyclin-dependent kinase 2 (CDK2) binding effects, 347 flavonoid derivatives were docked into the crystal structure of the CDK2. The docking study showed that gossypin has a good conformational match with CDK2, which was confirmed by the binding affinity assay using NMR experiments.
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