Metabolic syndrome and ischemic stroke risk: Northern Manhattan Study
Bernadette Boden-Albala1, Ralph L Sacco, Hye-Sueng Lee
1Department of Neurology, Columbia University College of Physicians and Surgeons, Mailman School of Public Health, New York, NY, USA. bb87@columbia.edu
Stroke
|December 8, 2007
Summary
The metabolic syndrome significantly increases stroke risk, particularly in women and Hispanic individuals. Addressing this condition could substantially reduce stroke incidence across diverse populations.
Area of Science:
- Cardiovascular epidemiology
- Metabolic disorders
- Neurology
Background:
- Metabolic syndrome affects over 47 million Americans.
- Its impact on stroke risk in multiethnic groups requires further clarification.
Purpose of the Study:
- To investigate the association between metabolic syndrome and ischemic stroke risk.
- To examine differential effects by sex and race/ethnicity.
Main Methods:
- Prospective follow-up of 3298 stroke-free residents in the Northern Manhattan Study.
- Metabolic syndrome defined by National Cholesterol Education Program Adult Treatment Panel III criteria.
- Cox proportional-hazards models used to assess stroke and vascular event risks.
Main Results:
- Metabolic syndrome present in over 44% of the cohort, more common in women and Hispanics.
- Metabolic syndrome associated with increased risk of stroke (HR=1.5) and vascular events (HR=1.6).
- Higher stroke risk observed in women (HR=2.0) and Hispanics (HR=2.0) with metabolic syndrome.
Conclusions:
- Metabolic syndrome is a significant risk factor for ischemic stroke.
- Sex and race/ethnicity modify the stroke risk associated with metabolic syndrome.
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