Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Growth hormone and bone.

R Bouillon1

  • 1Catholic University of Leuven, Laboratory of Experimental Medicine and Endocrinology, Belgium.

Hormone Research
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Growth hormone (GH) benefits bone health by increasing bone mass and lean body mass. However, excessive GH poses risks like osteoarthritis, leaving its role in osteoporosis treatment undefined.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Consensus statement from 2<sup>nd</sup> International Conference on Controversies in Vitamin D.

Reviews in endocrine & metabolic disorders·2020
Same author

Calcifediol or vitamin D to optimize vitamin D status: Reply to letter of M Sosas.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2019
Same author

Vitamin D and cardiovascular disorders.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2019
Same author

Sunscreen photoprotection and vitamin D status.

The British journal of dermatology·2019
Same author

Is calcifediol better than cholecalciferol for vitamin D supplementation?

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2018
Same author

How much vitamin D is needed for healthy bones?

Journal of internal medicine·2017
Same journal

Abstracts of the LWPES/ESPE 8th Joint Meeting Global Care in Paediatric Endocrinology, in collaboration with APEG, APPES, JSPE and SLEP. New York City, New York, USA. September 9-12, 2009.

Hormone research·2011
Same journal

Abstracts of the 47th Annual Meeting of the European Society for Paediatric Endocrinology (ESPE). Istanbul, Turkey. September 20-23, 2008.

Hormone research·2011
Same journal

Abstracts of the 46th Annual Meeting of the European Society for Paediatric Endocrinology (ESPE). Helsinki, Finland. June 27-30, 2007.

Hormone research·2011
Same journal

Genetic and pathogenetic aspects of Noonan syndrome and related disorders.

Hormone research·2009
Same journal

Response to growth hormone in short children with Noonan syndrome: correlation to genotype.

Hormone research·2009
Same journal

Growth hormone and the heart in Noonan syndrome.

Hormone research·2009
See all related articles

Area of Science:

  • Endocrinology
  • Bone Biology
  • Mineral Metabolism

Background:

  • Bone and mineral metabolism are complex processes regulated by hormones and local growth factors.
  • Growth hormone (GH) plays a significant role in modulating bone turnover and mineral homeostasis.
  • The precise mechanisms of GH's effects on bone resorption require further elucidation.

Purpose of the Study:

  • To summarize the multifaceted effects of growth hormone (GH) on bone and mineral metabolism.
  • To explore GH's influence on bone formation, resorption, and mineral absorption.
  • To evaluate the potential benefits and risks of GH in the context of bone health and osteoporosis.

Main Methods:

  • Review of existing literature on growth hormone (GH) and its impact on bone metabolism.

Related Experiment Videos

  • Analysis of GH's direct and indirect effects via IGF1 and IGF2 on osteoblast activity and bone resorption.
  • Examination of GH's role in regulating vitamin D activation and renal phosphate reabsorption.

    • Main Results:

    • GH, directly or via IGF1/IGF2, stimulates osteoblast number and function, increasing bone turnover.
    • GH enhances intestinal calcium and phosphate absorption by stimulating renal 25-hydroxyvitamin D-1 alpha-hydroxylase activity.
    • GH increases maximal renal tubular reabsorption of phosphate, contributing to overall bone health.
    • While GH increases bone and lean body mass, excess GH is linked to osteoarthritis and other metabolic issues.

    Conclusions:

    • GH generally promotes beneficial effects on bone mass and lean body mass.
    • The role of GH in osteoporosis treatment or prevention remains uncertain due to potential adverse effects of excess GH.
    • Further research is needed to define the therapeutic window for GH in bone health management.