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ConoServer, a database for conopeptide sequences and structures.

Quentin Kaas1, Jan-C Westermann, Reena Halai

  • 1Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, 4072, Australia.

Bioinformatics (Oxford, England)
|December 11, 2007
PubMed
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ConoServer is a new database for conopeptides, venom peptides from marine snails. This resource aids research into conopeptides as potential drug leads and physiological tools due to their ion channel blocking properties.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Bioinformatics

Background:

  • Marine snails of the genus Conus produce venom containing conopeptides.
  • Conopeptides exhibit diverse sequences and chemical modifications.
  • These peptides are valuable as drug leads and physiological research tools due to their ion channel blocking capabilities.

Purpose of the Study:

  • To introduce ConoServer, a novel database for conopeptides.
  • To provide a standardized classification and data retrieval system for conopeptide research.

Main Methods:

  • Data compilation from SwissProt, GenBank, Protein DataBank, and scientific literature.
  • Development of a genetic and structural classification scheme.
  • Implementation of specialized web features, including graphic display of post-translational modifications.

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Main Results:

  • ConoServer currently manages 1214 nucleic acid sequences from 54 Conus species.
  • The database contains 2258 protein sequences from 66 Conus species.
  • 99 3D structures of conopeptides are available in ConoServer.

Conclusions:

  • ConoServer offers a comprehensive and organized resource for conopeptide research.
  • The database facilitates the study of conopeptide diversity, function, and therapeutic potential.
  • Specialized features enhance the visualization and analysis of conopeptide data.