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Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

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Polycystic kidneys: a cautionary story.

R J Currie¹, S J Freeman, F McCormick

¹Department of Radiology, Derriford Hospital, Plymouth PL6 8DH, UK.

The British Journal of Radiology

|December 11, 2007

Summary

This study details a rare case of bilateral, synchronous renal cell carcinoma mimicking autosomal dominant polycystic kidney disease (ADPKD). This cystic presentation highlights a critical diagnostic challenge in nephrology.

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Published on: September 1, 2015

Area of Science:

Nephrology
Oncology
Radiology

Background:

Bilateral, synchronous renal cell carcinoma (RCC) is uncommon.
Renal cell carcinoma can present with cystic features, posing diagnostic challenges.
Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disorder characterized by numerous cysts in the kidneys.

Observation:

A patient presented with progressive chronic renal failure.
Imaging revealed bilateral, multiloculated, predominantly cystic renal masses.
These findings were initially misdiagnosed as autosomal dominant polycystic kidney disease (ADPKD).

Findings:

The patient was diagnosed with bilateral, synchronous, multiloculated renal cell carcinoma.
The cystic nature and bilateral involvement mimicked ADPKD.
This represents the first reported case of renal cell carcinoma imitating ADPKD due to cystic replacement of renal parenchyma.

Implications:

Highlights the importance of considering malignancy in cystic renal masses, even when resembling ADPKD.
Emphasizes the need for careful radiological assessment and differential diagnosis in complex renal imaging.
Underscores the potential for rare presentations of renal cell carcinoma to mimic common renal diseases.