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Related Experiment Videos

Phantom studies and preliminary clinical experience with the BSD 2000.

R J Myerson1, L Leybovich, B Emami

  • 1Radiation Oncology Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri.

International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
|November 1, 1991
PubMed
Summary

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The BSD 2000 system effectively delivers regional hyperthermia, with computer predictions showing good agreement with measured specific absorption rate (SAR) distributions. Clinical use demonstrated therapeutic temperatures in most patients, with notable treatment responses.

Area of Science:

  • Medical Physics
  • Oncology
  • Biomedical Engineering

Background:

  • Regional hyperthermia using microwave antennas can enhance cancer treatment efficacy.
  • Accurate prediction and measurement of specific absorption rate (SAR) distributions are crucial for effective and safe hyperthermia delivery.
  • The BSD 2000 system offers phase control for targeted energy deposition and includes a computer preplanning system.

Purpose of the Study:

  • To validate the accuracy of the BSD 2000 system's computer preplanning by comparing predicted SAR distributions with measured data.
  • To assess the system's performance in achieving therapeutic temperatures in clinical hyperthermia treatments.
  • To evaluate preliminary clinical outcomes and identify any adverse events associated with the treatment.

Main Methods:

Related Experiment Videos

  • Comparison of computer-predicted SAR distributions with measured SAR in muscle equivalent phantoms and pig cadavers.
  • Measurement of longitudinal SAR dependence and spinal canal SAR.
  • Review of preliminary clinical data from 17 patients undergoing hyperthermia treatment with the BSD 2000 system, including thermal mapping and response assessment.

Main Results:

  • Computer predictions of SAR distribution showed qualitative agreement with measurements, with minor discrepancies in iso-SAR contour locations (3-5 cm).
  • The 50% iso-SAR covered a length of 15-20 cm, and spinal canal SAR was significantly reduced using steering techniques, aligning with preplan predictions.
  • Therapeutic temperatures (≥42°C for ≥30 min) were achieved in 61% of treatment sessions, with 77% of monitored tumor points reaching this threshold.
  • Five complete and seven partial responses were observed among the 17 patients.

Conclusions:

  • The BSD 2000 system, with its computer preplanning, provides a reasonably accurate method for predicting SAR distributions in regional hyperthermia.
  • Steering techniques effectively reduce SAR in sensitive areas like the spinal canal.
  • The system is capable of achieving therapeutic temperatures, leading to positive clinical responses in a significant portion of patients, although cardiovascular stress was noted in two cases.