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Related Concept Videos

The Mammary Glands01:12

The Mammary Glands

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Related Experiment Video

Updated: Jul 9, 2026

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy
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Published on: June 1, 2019

When sentinel lymph node is intramammary.

Mattia Intra1, Carlos A Garcia-Etienne, Giuseppe Renne

  • 1Breast Surgery Department, European Institute of Oncology, Via Ripamonti 435, Milan, MI 20141, Italy. mattia.intra@ieo.it

Annals of Surgical Oncology
|December 11, 2007
PubMed
Summary
This summary is machine-generated.

Intramammary sentinel lymph nodes (intraMSLNs) can be positive in early-stage breast cancer patients. Biopsying both intraMSLNs and axillary sentinel lymph nodes (axSLNs) improves staging, but axillary management should still rely on axSLN status.

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Area of Science:

  • Oncology
  • Surgical Pathology

Background:

  • Sentinel lymph node biopsy (SLNB) is standard for early-stage breast cancer axillary staging.
  • Preoperative lymphoscintigraphy has largely overlooked intramammary sentinel lymph nodes (intraMSLNs).

Purpose of the Study:

  • To investigate the significance of intraMSLNs identified on preoperative lymphoscintigraphy.
  • To evaluate the impact of intraMSLN status on breast cancer staging and axillary management.

Main Methods:

  • Lymphoscintigraphy was performed on 9632 early-stage breast cancer patients with clinically uninvolved axillary nodes.
  • Intramammary sentinel lymph nodes (intraMSLNs) were identified in 0.2% of cases, often alongside axillary sentinel lymph nodes (axSLNs).
  • Both intraMSLNs and axSLNs were excised in 15 patients for analysis.

Main Results:

  • Positive intraMSLNs were found in 6/15 patients (40%), with micrometastases in 3.
  • All corresponding axillary sentinel lymph nodes (axSLNs) were negative in these 15 patients.
  • No locoregional or systemic recurrences were observed at a median 24-month follow-up.

Conclusions:

  • Positive intraMSLNs can enhance disease staging in breast cancer.
  • IntraMSLN positivity does not necessarily indicate axillary lymph node metastasis.
  • Management of the axilla should prioritize axillary sentinel lymph node (axSLN) status, even with positive intraMSLNs.