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Related Experiment Video

Updated: Jul 9, 2026

Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging

Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging

Published on: May 24, 2021

Molecular imaging by cardiovascular MR.

Tillmann Cyrus¹, Gregory M Lanza, Samuel A Wickline

¹Division of Cardiology, Washington University School of Medicine, St. Louis, MO 63108, USA.

Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance

|December 11, 2007

Summary

This summary is machine-generated.

Molecularly-targeted nanoparticles represent a paradigm shift in cardiovascular disease imaging and treatment. These "intelligent" contrast agents enable non-invasive detection of vulnerable atherosclerotic plaque for preemptive therapeutic interventions.

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Published on: February 16, 2016

Area of Science:

Cardiovascular Imaging
Nanomedicine
Molecular Imaging

Background:

Cardiovascular diseases remain a leading cause of mortality worldwide.
Current imaging techniques for atherosclerosis have limitations in detecting vulnerable plaque.
Molecularly-targeted contrast agents offer potential for improved diagnostic and therapeutic capabilities.

Purpose of the Study:

To explore the potential of molecularly-targeted nanoparticle technology in cardiovascular imaging.
To assess the feasibility of non-invasive vulnerable plaque detection and treatment using these agents.
To review advancements in "intelligent" contrast agents for cardiovascular magnetic resonance (MR) imaging.

Main Methods:

Review of recent developments in molecularly-targeted nanoparticle contrast agents.
Focus on applications in cardiovascular magnetic resonance (MR) imaging.
Discussion of complementary advanced imaging technologies.

Main Results:

Molecularly-targeted nanoparticles show promise for detecting atherosclerotic lesions.
These agents may allow for determination of lesion clinical significance.
Potential for non-invasive therapeutic applications is highlighted.

Conclusions:

Molecularly-targeted nanoparticle technology may revolutionize cardiovascular disease detection and management.
Non-invasive vulnerable plaque imaging and preemptive treatment are nearing clinical application.
The integration of "intelligent" contrast agents with advanced imaging offers a new frontier in cardiovascular medicine.