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Updated: Aug 1, 2026

A Novel Stretching Platform for Applications in Cell and Tissue Mechanobiology
Published on: June 3, 2014
Stress proteins and cardiovascular disease
1Molecular Cardiology Research Laboratories, University of Texas Southwestern Medical Center, Dallas 75235-8573.
Abstract:
Understanding the molecular basis by which cells of the heart and blood vessels adapt to physiological stress conditions is an important goal for cardiovascular investigators. The ubiquitous heat shock response provides a model for cellular adaptations to metabolic stresses that are encountered in cardiac disease. Stress-induced synthesis of a family of highly conserved proteins serves to protect cells from injury. In addition, members of this family have essential roles in protein processing and assembly of macromolecular complexes, and in regulation of gene expression, even in unstressed cells. Research concerning the regulation and function of stress proteins potentially is pertinent to the pathophysiology of myocardial hypertrophy, remodeling, and failure, to age-related changes in the cardiovascular system, as well as to ischemic heart disease.
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