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Published on: June 10, 2025

Prognosis of hospitalized new-onset systolic heart failure in Indo-Asians--a lethal problem

Fahim H Jafary1, Mahesh Kumar, Irfan E Chandna

  • 1Department of Medicine, Section of Cardiology, Aga Khan University Hospital, Karachi, Pakistan.

Journal of Cardiac Failure
|December 11, 2007
PubMed

Insights

Hospitalized systolic heart failure (SHF) patients in Indo-Asians face a poor prognosis. Key predictors of death include low serum sodium, high admission pulse, low systolic blood pressure, and severe mitral regurgitation.

Area of Science:

  • Cardiology
  • Internal Medicine
  • Public Health

Background:

  • Systolic heart failure (SHF) hospitalization indicates a poor prognosis, especially in Indo-Asians where cardiovascular disease is rising.
  • Limited data exists on SHF outcomes in the Indo-Asian population.

Purpose of the Study:

  • To determine the frequency and predictors of mortality and morbidity in patients admitted with new-onset SHF in Pakistan.

Main Methods:

  • Retrospective review of 196 new-onset SHF patients (ejection fraction <40%) at a tertiary care hospital.
  • Kaplan-Meier survival analysis and Cox regression modeling were used.
  • Exclusion criteria included in-hospital death, life-limiting concomitant disease, and lack of follow-up.

Main Results:

  • The mean age was 61 years, with 77% having prior ischemic heart disease and a mean ejection fraction of 25%.
  • Median follow-up was 379 days. 27.5% died, and 52% experienced death or re-hospitalization for SHF.
  • Independent predictors of death were lower serum sodium, higher admission pulse, lower systolic blood pressure, and severe mitral regurgitation.

Conclusions:

  • Admission for new-onset SHF portends a grave 1-year prognosis for Indo-Asians.
  • Preventing ischemic heart disease is crucial, as developing nations face significant challenges in managing heart failure.
Abstract

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