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Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

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Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
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Exercise training promotes SIRT1 activity in aged rats.

Nicola Ferrara1, Barbara Rinaldi, Graziamaria Corbi

  • 1Department of Health Sciences, Faculty of Medicine, University of Molise, Campobasso, Italy.

Rejuvenation Research
|December 12, 2007
PubMed
Summary

Exercise training boosts SIRT1 activity, counteracting age-related decline in heart and adipose tissues. This enhances antioxidant response and cell cycle regulation, improving overall systems function in aged rats.

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Area of Science:

  • Biogerontology
  • Exercise Physiology
  • Molecular Biology

Background:

  • Sirtuin 1 (SIRT1) is a key NAD(+)-dependent deacetylase implicated in oxidative stress and aging.
  • The impact of aging and exercise on SIRT1 activity, antioxidant response, and cell cycle regulation in rats remains largely unexplored.

Purpose of the Study:

  • To investigate the effects of aging and exercise training on SIRT1 activity in rat heart and adipose tissue.
  • To elucidate the pathway linking SIRT1 to antioxidant defense and cell cycle control.

Main Methods:

  • SIRT1 activity was measured using assay kits.
  • Oxidative damage was assessed via TBARS and 4-HNE levels.
  • Protein and mRNA expression of MnSOD, catalase, FOXO3a, GADD45a, and cyclin D(2) were analyzed using Western blot and RT-PCR.

Main Results:

  • Aging reduced SIRT1 activity and antioxidant enzyme expression (Mn-SOD, catalase) while increasing oxidative damage (TBARS, 4-HNE) in the heart.
  • Exercise training increased SIRT1 activity, FOXO3a, Mn-SOD, and catalase in aged rats' hearts and adipose tissues.
  • Exercise modulated cell cycle regulators (cyclin D(2), GADD45a) in conjunction with SIRT1 activity.

Conclusions:

  • Exercise training can enhance SIRT1 activity, thereby mitigating age-associated impairments in antioxidant capacity and cell cycle regulation.
  • SIRT1 plays a crucial role in mediating the beneficial effects of exercise against aging-related decline.