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Updated: Jul 9, 2026

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
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Clinical uses of interferons
1Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA. rfriedman@usuhs.mil
Interferons were first described by Isaacs & Lindenmann working at the National Institute for Medical Research, Mill Hill in 1957. Thus, the fiftieth year of their discovery is being celebrated this year at Oxford in a meeting of the International Society for Interferon and Cytokine Research. This then is an appropriate time to review the clinical applications of the interferons. To accomplish this coherently it is necessary also to review briefly what led to the discovery of interferons, why their clinical applications were so slow in coming, and the impact of interferon research on the biomedical sciences.
Interferons were first described by Isaacs & Lindenmann working at the National Institute for Medical Research, Mill Hill in 1957. Thus, the fiftieth year of their discovery is being celebrated this year at Oxford in a meeting of the International Society for Interferon and Cytokine Research. This then is an appropriate time to review the clinical applications of the interferons. To accomplish this coherently it is necessary also to review briefly what led to the discovery of interferons, why their clinical applications were so slow in coming, and the impact of interferon research on the biomedical sciences.
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