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Related Experiment Video

Updated: Jul 9, 2026

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes

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Clinical uses of interferons.

Robert M Friedman¹

¹Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA. rfriedman@usuhs.mil

British Journal of Clinical Pharmacology

|December 12, 2007

Summary

This review celebrates 50 years of interferon discovery, examining their clinical applications, historical context, and impact on biomedical sciences. It explores the slow development of clinical uses for interferons.

Area of Science:

Immunology
Virology
Biochemistry

Background:

Interferons were discovered in 1957 by Isaacs and Lindenmann.
The year marks the 50th anniversary of interferon discovery.
A meeting of the International Society for Interferon and Cytokine Research is being held in Oxford.

Purpose of the Study:

To review the clinical applications of interferons.
To briefly review the history leading to interferon discovery.
To discuss the reasons for the slow development of clinical applications.
To assess the impact of interferon research on biomedical sciences.

Main Methods:

Literature review of interferon discovery and clinical applications.
Historical analysis of research progress.

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Discussion of challenges in clinical translation.

Assessment of broader scientific impact.

Main Results:

Interferons have a significant history dating back 50 years.
The clinical applications of interferons have evolved over time.
Several factors contributed to the delayed clinical use of interferons.
Interferon research has profoundly influenced the biomedical field.

Conclusions:

The review provides a comprehensive overview of interferons.
Understanding the history and challenges is crucial for future applications.
Interferons continue to be a vital area of biomedical research.