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Fiberoptic array for multiple channel infrared neural stimulation of the brain
Mykyta M Chernov1, Robert M Friedman1, Anna W Roe1
1Oregon Health and Science University, Oregon National Primate Research Center, Division of Neuroscience, Beaverton, Oregon, United States.
Neurophotonics
|April 26, 2021
Summary
We developed a new infrared neural stimulation (INS) method using a rapidly switched fiber array to precisely modulate brain activity at multiple locations. This technique offers high spatial and temporal control without genetic modification.
Area of Science:
- Neuroscience
- Biomedical Engineering
- Optical Methods
Background:
- Infrared neural stimulation (INS) has been limited to single-point stimulation.
- Developing multi-point stimulation is crucial for advanced neuroscience research.
Purpose of the Study:
- To develop and validate a rapidly switched fiber array for multi-point infrared neural stimulation.
- To achieve precise spatial and temporal control of cortical activity.
Main Methods:
- Utilized a solid-state infrared laser, a piezoelectric fiber coupled optical switch, and optical fibers.
- Validated the device using intrinsic optical signal imaging in primate sensory cortex.
Main Results:
- Demonstrated consistent generation of neural responses in primate cortex using the switched array.
- Confirmed the ability to target single or multiple cortical surface regions.
Conclusions:
- The developed INS array enables precise, multi-point cortical modulation.
- The method is compatible with other stimulation and recording techniques, offering broad applicability.
