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[Role of heat shock protein 47 on experimental diabetic nephropathy of rats]

Dian-ge Liu, Qing-juan Zhang, Zhuang Gong

    Zhonghua Bing Li Xue Za Zhi = Chinese Journal of Pathology
    |December 12, 2007
    PubMed
    Abstract

    No abstract available in PubMed .

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    Diabetic Nephropathy

    Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...