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Studies on the later stage of the biosynthesis of pleuromutilin
Tae Tsukagoshi1, Tetsuo Tokiwano, Hideaki Oikawa
1Division of Chemistry, Graduate School of Science, Hokkaido University, Sapporo, Japan.
Abstract:
Mutilin (4) and deoxy analogues 2 and 3 are biosynthetic precursors of pleuromutilin (1) in the later stage of biosynthesis. Precursors 2 and 3 are required for studies on the oxygenation steps in biosynthesis, and were synthesized from readily available 1 via 4 by deoxygenation of the hydroxy groups. Feeding experiments with the (2)H-labeled precursors confirmed their microbial conversion into 1.
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