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Therapeutic interference: a step closer for pachyonychia congenita?
1Department of Dermatology, University of California, Irvine, Irvine, California 92697, USA. erugg@uci.edu
The Journal of Investigative Dermatology
|December 12, 2007
Abstract:
The identification of mutations in keratin genes as the cause of several inherited skin disorders raised the possibility that molecular-based therapies might be developed to treat these conditions. In this issue, Smith et al. (2007) have identified small interfering RNAs that specifically and potently silence keratin 6a expression. These molecules have great promise as therapeutic agents for the treatment of pachyonychia congenita.