Related Experiment Video
Updated: Jul 9, 2026

Organotypic Cerebellar Cultures: Apoptotic Challenges and Detection
Published on: May 17, 2011
Apoptosis of the cerebellar neurons
Laura Lossi1, Graziana Gambino
1Department of Veterinary Morphophysiology, University of Torino, and Istituto Nazionale di Neuroscienze, Italy. laura.lossi@unito.it.
Abstract:
Naturally occurring neuronal death (NOND) is an essential phenomenon during the course of normal development of the nervous system. Studies in vivo and on organotypic cultures have helped to elucidate the basic histological and ultrastructural features, as well as the main cellular mechanisms of NOND in several areas of the brain. This review examines the existing evidence about the two waves of apoptotic cell death that affect the different types of cerebellar neurons in normal development and certain pathological conditions. The first wave regards neuronal progenitors and pre-migratory neuroblasts, the second post-migratory neuroblasts and mature neurons. The underlying cellular and molecular mechanisms are discussed critically also in the light of their relevance to neurodegenerative diseases.
Related Concept Videos
Apoptosis
Overview of Cell Death
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the 20th century...
Autophagic Cell Death
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and pro-apoptotic...
Phagocytosis of Apoptotic Cells
Normal cells contain receptors that prevent them from being recognized by phagocytes.
Caspases
Cellular Injury V: Apoptosis and Autophagy

