Related Experiment Video
Updated: Jul 9, 2026
12:08
Tracking Mouse Bone Marrow Monocytes In Vivo
Published on: February 27, 2015
Notochordal inclusions in the vertebral bone marrow
Alessandro Corsi1, Fernando De Maio, Federico Mancini
1Dipartimento di Medicina Sperimentale, Università La Sapienza, Rome, Italy.
Summary
Nontumoral notochordal inclusions in bone marrow can mimic serious conditions on MRI scans. Early identification prevents unnecessary concern and overtreatment for these benign vertebral lesions.
Area of Science:
- Spinal imaging and pathology
- Developmental biology of the notochord
Background:
- Notochordal remnants can persist within vertebral bone marrow.
- These inclusions are distinct from neoplastic lesions like chordomas.
- Understanding their origin is crucial for accurate diagnosis.
Observation:
- A case of nontumoral notochordal inclusions presenting as an MRI-detectable lesion is described.
- The lesion showed no evidence of osteolysis (bone destruction).
- This presentation can be mistaken for other pathologies.
Findings:
- Nontumoral notochordal inclusions arise from displaced notochordal cells.
- These cells proliferate within the bone marrow microenvironment.
- The resulting lesion is MRI-detectable but non-neoplastic.
Implications:
- Accurate MRI interpretation is key to avoid misdiagnosis.
- Awareness of these lesions can prevent unnecessary patient anxiety.
- This understanding may reduce overtreatment of benign conditions.
Related Concept Videos
01:30General Structure of a Vertebra
A typical vertebra, with the exception of the sacrum and coccyx, consists of a body, a vertebral arch, and seven different projections termed processes. The anterior portion of the vertebrae, the body, supports about half the body’s weight. The vertebral bodies progressively increase in size and thickness from the cervical region to the lumbar region of the vertebral column. The intervertebral discs present between the bodies of adjacent vertebrae firmly unites them, forming a continuous column.
01:24Bone Formation by Endochondral Ossification
Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
01:27Compact Bone
Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
01:09Spongy Bone
All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
01:15Spinal Cord: Gross Anatomy
The spinal cord resides within the protective confines of the vertebral column. It is the main pathway for information traveling between the brain and the body. It plays a fundamental role in nearly all bodily functions, from simple reflexes to complex motor movements. The spinal cord begins at the medulla oblongata at the base of the brainstem and extends downward, terminating at the conus medullaris near the first and second lumbar vertebrae. The spinal cord's length in adults is...
01:23Bone as Supporting Connective Tissue
Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...