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Papular acantholytic dyskeratosis presenting as genital warts
Fiona Browne1, Helen Keane, Maureen Walsh
1Department of Genitourinary Medicine, Royal Victoria Hospital, Grosvenor Road, Belfast BT12 6HB, UK. fmbrowne@hotmail.com
International Journal of STD & AIDS
|December 13, 2007
Summary
A rare case of Darier's disease presented solely as genital warts in a young woman. This suggests a localized form of the condition, termed genital papular acantholytic dyskeratosis.
Area of Science:
- Dermatology
- Genetics
- Pathology
Background:
- Darier's disease is a rare autosomal dominant skin disorder.
- Typically presents with characteristic skin lesions, nail changes, and palmoplantar keratoderma.
- Genital involvement is uncommon and often atypical.
Observation:
- A 24-year-old woman presented with recalcitrant genital warts.
- Standard treatments for genital warts were ineffective.
- Skin biopsy revealed histopathological features consistent with Darier's disease.
Findings:
- The patient lacked other typical manifestations of Darier's disease, such as family history, nail abnormalities, or widespread skin lesions.
- The unique presentation led to the proposal of a localized variant: genital papular acantholytic dyskeratosis.
Implications:
- This case expands the clinical spectrum of Darier's disease.
- Highlights the importance of considering genodermatoses in atypical presentations of common conditions.
- Suggests that Darier's disease can manifest with unique localized phenotypes.
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