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Related Experiment Video

Updated: Jul 9, 2026

Induced Differentiation of M Cell-like Cells in Human Stem Cell-derived Ileal Enteroid Monolayers
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Published on: July 26, 2019

Activin A stimulates IgA expression in mouse B cells.

Hwa-Joung Lee1, Goo-Young Seo, Hyun-A Kim

  • 1Department of Molecular Bioscience, School of Bioscience & Biotechnology, Kangwon National University, Chunchon 200-701, Republic of Korea.

Biochemical and Biophysical Research Communications
|December 13, 2007
PubMed
Summary

Activin A promotes immunoglobulin A (IgA) production in B cells by increasing germ-line alpha transcription. This process involves the Smad3/4 signaling pathway, highlighting activin A

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Published on: December 1, 2014

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • Immunoglobulin A (IgA) is crucial for mucosal immunity.
  • Regulation of IgA isotype switching is complex and involves various signaling pathways.
  • Activin A is a growth factor with diverse biological functions.

Purpose of the Study:

  • To investigate the role of activin A in the regulation of immunoglobulin (Ig) production in mice.
  • To elucidate the molecular mechanisms by which activin A influences IgA synthesis.

Main Methods:

  • B lymphoma and normal B cells were treated with activin A.
  • Ig secretion and surface Ig expression were measured.
  • Germ-line alpha and post-switch alpha transcript levels were analyzed.
  • Activin receptor inhibitor (SB431542) and Smad3/4 manipulation were employed.

Main Results:

  • Activin A significantly increased IgA secretion and surface IgA expression in B cells.
  • Activin A elevated germ-line alpha transcript (GLT(alpha)) and post-switch transcripts alpha (PST(alpha)) levels.
  • The effects of activin A were mediated via Smad3/4 signaling and blocked by SB431542.

Conclusions:

  • Activin A induces IgA isotype switching in B cells.
  • The mechanism involves Smad3/4-mediated germ line alpha transcription.
  • Activin A represents a novel regulator of IgA production.