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Updated: Jul 9, 2026
06:44
Induction and Evaluation of Inbreeding Crosses Using the Ant, Vollenhovia Emeryi
Published on: October 5, 2018
Inbreeding in genome-wide selection.
H D Daetwyler1, B Villanueva, P Bijma
1Genetics and Genomics, Roslin Institute Edinburgh, Roslin, Midlothian, UK. hans.daetwyler@bbsrc.ac.uk
Summary
Genome-wide selection increases genetic gain and reduces inbreeding rate (DeltaFG) compared to traditional methods like BLUP. This is achieved by improving breeding value accuracy and better prediction of Mendelian sampling terms.
Area of Science:
- Animal Breeding and Genetics
- Quantitative Genetics
- Genomic Selection
Background:
- Traditional selection methods (sib, BLUP) increase genetic gain but also the rate of inbreeding per generation (DeltaFG).
- Genome-wide selection offers increased genetic gain through enhanced accuracy.
Purpose of the Study:
- To explain why genome-wide selection reduces DeltaFG compared to sib and BLUP selection.
- To elucidate the mechanisms behind reduced inbreeding in genome-wide selection.
Main Methods:
- Comparative analysis of selection methods (sib, BLUP, genome-wide).
- Focus on prediction accuracy of estimated breeding values.
- Evaluation of Mendelian sampling term contribution.
Main Results:
- Genome-wide selection achieves higher accuracy by better predicting the Mendelian sampling term.
- This leads to increased differentiation between siblings, reducing coselection and DeltaFG.
- Reduced between-family variance and lower intraclass correlations in genome-wide selection further decrease coselection.
Conclusions:
- Genome-wide selection enables higher genetic gain while simultaneously reducing the rate of inbreeding.
- It offers a more efficient approach to animal breeding compared to traditional methods.
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