HLA-A*11:518, A Novel Allele With Elevated Grantham Distance and Predicted Thermodynamic Instability
Benjamin A Asghar1, Tricia Crawford1, Dana Collins1
1McLendon Laboratories, University of North Carolina Medical Center, Chapel Hill, North Carolina, USA.
HLA
|July 13, 2026
Summary
A new human leukocyte antigen (HLA) variant, HLA-A*11:518, has been identified. This variant differs from HLA-A*11:01:01:01 due to a specific missense mutation in exon 2.
Area of Science:
- Immunogenetics
- Molecular biology
Background:
- The human leukocyte antigen (HLA) system is crucial for immune response.
- HLA-A alleles play a significant role in T-cell recognition and transplantation compatibility.
Purpose of the Study:
- To characterize a novel HLA-A allele, designated HLA-A*11:518.
- To describe the genetic basis of this new HLA-A variant.
Main Methods:
- Sequence analysis of HLA-A gene.
- Comparison with known HLA-A alleles.
Main Results:
- Identification of HLA-A*11:518 as a distinct allele.
- The variant arises from a missense mutation in exon 2 of the HLA-A gene.
- HLA-A*11:518 is closely related to HLA-A*11:01:01:01.
Conclusions:
- The discovery of HLA-A*11:518 expands the known diversity of HLA-A alleles.
- Understanding such variations is vital for high-resolution HLA typing and personalized medicine.
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