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Related Experiment Video

Updated: Jul 9, 2026

Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots

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Fat and expanded act in parallel to regulate growth through warts.

Yongqiang Feng¹, Kenneth D Irvine

¹Howard Hughes Medical Institute, Waksman Institute, and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.

Proceedings of the National Academy of Sciences of the United States of America

|December 14, 2007

Summary

Overexpressing Warts rescues mutations in Fat and Expanded, revealing their primary role in regulating Warts tumor suppressor activity and growth control in Drosophila.

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Area of Science:

Developmental Biology
Cell Biology
Genetics

Background:

The tumor suppressors Fat and Expanded in Drosophila are implicated in regulating Warts.
Disagreement exists regarding the precise interactions among Fat, Expanded, and Warts and their role in growth control.

Purpose of the Study:

To clarify the functional relationship between Fat, Expanded, and Warts.
To investigate the significance of these interactions for Drosophila growth regulation.

Main Methods:

Genetic rescue experiments involving overexpression of Warts.
Analysis of Fat and Expanded interactions and their effects on imaginal disk growth.

Main Results:

Overexpression of Warts rescues viability in expanded or fat mutants, highlighting their influence on Warts.
Fat signaling's transcriptional and planar cell polarity branches are separable; Expanded does not directly impact polarity.
Fat and Expanded exhibit additive effects on imaginal disk growth, contrary to previous findings.
Fat mutation causes partial loss of Expanded protein but still promotes growth when Expanded is overexpressed.

Conclusions:

Fat and Expanded primarily function by influencing Warts activity, not through endocytosis or other pathways.
These findings challenge models of Fat acting solely as a Hippo pathway receptor.
Fat and Expanded likely act in parallel pathways to regulate Warts through distinct mechanisms.