New cytotoxic 14-membered macrolides from marine-derived fungus Aspergillus ostianus
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Assessing the Putative Anticryptococcal Properties of Crude and Clarified Extracts from Mollusks
Published on: December 2, 2022
Keijiro Kito1, Ryuhei Ookura, Sanae Yoshida
1Faculty of Pharmaceutical Sciences, The University of Tokushima, Tokushima 770-8505, Japan.
Abstract:
Three new 14-membered macrolides, named aspergillides A, B, and C (1, 5, and 7), were isolated from marine-derived fungus Aspergillus ostianus strain 01F313, cultured in a medium composed of bromine-modified artificial seawater. The structures of the new compounds were determined by analyses of 1D and 2D NMR spectra. Their absolute configurations were elucidated by the modified Mosher's method and chemical conversions. The new compounds showed cytotoxic activity against mouse lymphocytic leukemia cells (L1210).
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