Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chronic Pancreatitis I: Introduction

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...

Chronic Pancreatitis I: Introduction

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...

Chronic Pancreatitis II: Pathophysiology

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...

Acute Pancreatitis I: Introduction

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...

Acute Pancreatitis I: Introduction

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:

Acute Pancreatitis II: Pathophysiology

Acute Pancreatitis II: Pathophysiology

The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The use of endoscopic ultrasonography and other imaging modalities in the preoperative staging of rectal villous tumours: a case of overstaging by magnetic resonance imaging.

Canadian journal of gastroenterology = Journal canadien de gastroenterologie·2009

Same author

Screening of sugar beet tissue culture clones for resistance to rhizomania disease.

Pakistan journal of biological sciences : PJBS·2008

Same author

The use of budesonide in the treatment of autoimmune hepatitis in Canada.

Canadian journal of gastroenterology = Journal canadien de gastroenterologie·2008

Same author

Acute management and secondary prophylaxis of esophageal variceal bleeding: a western Canadian survey.

Canadian journal of gastroenterology = Journal canadien de gastroenterologie·2006

Same author

Retinal vein thrombosis associated with pegylated-interferon and ribavirin combination therapy for chronic hepatitis C.

World journal of gastroenterology·2006

Search research articles

Related Experiment Video

Updated: Jul 9, 2026

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice

Published on: January 9, 2026

Autoimmune pancreatitis: a review.

Iman Zandieh¹, Michael-F Byrne

¹Division of Gastroenterology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

World Journal of Gastroenterology

|December 18, 2007

Summary

Autoimmune pancreatitis is now a recognized condition that can mimic pancreatic cancer. Early diagnosis and understanding its features are key for appropriate management.

Area of Science:

Gastroenterology and Immunology

Background:

Autoimmune pancreatitis (AIP) has evolved from a debated concept to a well-established clinical entity over the past four decades.
AIP is a significant differential diagnosis for pancreatic carcinoma due to its similar presentation.
Accurate and timely diagnosis of AIP is critical to avoid misdiagnosis and ensure appropriate treatment.

Purpose of the Study:

To review the diagnostic advancements in autoimmune pancreatitis.
To highlight the key laboratory and imaging features of AIP.
To discuss proposed diagnostic criteria and treatment strategies for AIP.

Main Methods:

Review of characteristic laboratory findings in AIP.
Analysis of typical imaging features associated with AIP.
Examination of established diagnostic criteria and treatment algorithms for AIP.

More Related Videos

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion

Published on: February 28, 2021

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct

Published on: April 1, 2022

Related Experiment Videos

Last Updated: Jul 9, 2026

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice

Published on: January 9, 2026

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion

Published on: February 28, 2021

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct

Published on: April 1, 2022

Main Results:

AIP presents with distinct laboratory and imaging profiles.
Several diagnostic criteria have been proposed to aid in AIP identification.
Treatment algorithms are being refined based on improved understanding of AIP.

Conclusions:

Autoimmune pancreatitis is a distinct clinical entity with specific diagnostic markers.
Understanding AIP's pathogenesis and natural history has improved diagnostic accuracy.
Further refinement of diagnostic criteria and treatment protocols for AIP is ongoing.