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Stereotactic radiosurgery for Cushing disease: a review
1Department of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia 30322, USA. noyesik@emory.edu
Neurosurgical Focus
|December 18, 2007
Summary
Stereotactic radiosurgery offers an effective and safe treatment for Cushing disease (CD) in select patients. Future advancements in technology and radiobiology promise improved outcomes for this endocrine disorder.
Area of Science:
- Neurosurgery
- Endocrinology
- Radiation Oncology
Background:
- Cushing disease (CD) is a rare endocrine disorder caused by a pituitary adenoma leading to excessive cortisol production.
- Current treatment options for CD include surgery, medication, and radiation therapy.
- Stereotactic radiosurgery (SRS) has emerged as a viable therapeutic option for managing CD.
Purpose of the Study:
- To review the contemporary use of stereotactic radiosurgery (SRS) for treating Cushing disease (CD).
- To evaluate the efficacy and safety of SRS in managing CD based on literature and clinical experience.
Main Methods:
- Comprehensive literature review on stereotactic radiosurgery for Cushing disease.
- Analysis of clinical outcomes and safety profiles from published studies.
- Incorporation of author's personal experience in managing CD with SRS.
Main Results:
- Stereotactic radiosurgery is demonstrated as an effective treatment modality for Cushing disease.
- SRS presents a safe therapeutic alternative when applied to carefully selected patient cohorts.
- Evidence suggests a favorable risk-benefit profile for SRS in specific CD cases.
Conclusions:
- Stereotactic radiosurgery is a valuable and safe treatment option for select patients with Cushing disease.
- Ongoing advancements in imaging, dose planning, and radiobiology are expected to enhance SRS efficacy for CD.
- Further research and technological improvements will likely optimize future outcomes for SRS in CD management.
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