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Updated: Jul 9, 2026
08:03
Simultaneous Assessment of Cardiomyocyte DNA Synthesis and Ploidy: A Method to Assist Quantification of Cardiomyocyte Regeneration and Turnover
Published on: May 23, 2016
[Nuclear changes and p62 expression in ischemic and dilated cardiomyopathy]
Raquel Cortés1, Manuel Portolés, Esther Roselló-Lletí
1Unidad de Cardiología, Centro de Investigación, Hospital Universitario La Fe, Valencia, España.
Revista Espanola De Cardiologia
|December 18, 2007
Summary
Heart failure patients with ischemic or dilated cardiomyopathy show enlarged cell nuclei and nucleoli. Protein p62 levels doubled, correlating with nuclear changes in ischemic cardiomyopathy.
Area of Science:
- Cardiovascular Biology
- Cell Biology
- Molecular Cardiology
Context:
- Heart failure, a leading cause of mortality, involves complex cellular and molecular changes in cardiomyocytes.
- Investigating nuclear morphology and protein expression provides insights into disease mechanisms.
Purpose:
- To examine nuclear stereology and p62 protein levels in human cardiomyocytes from patients with ischemic cardiomyopathy (ICM) and dilated cardiomyopathy (DCM).
- To correlate nuclear structural changes with p62 protein levels in these conditions.
Summary:
- Cardiomyopathy hearts exhibited significantly enlarged nuclei and nucleoli compared to controls.
- p62 protein levels were substantially elevated in both ICM and DCM, approximately doubling in affected hearts.
- In ICM, increased p62 levels correlated with larger nuclear size and altered heterochromatin percentage.
Impact:
- Reveals significant alterations in cardiomyocyte nuclear structure and p62 protein expression in heart failure.
- Suggests a potential role for p62 in the pathobiology of ICM and DCM.
- Provides a basis for further research into therapeutic targets related to nuclear transport and protein regulation in heart failure.
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