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Related Experiment Videos

Intermediate filament assembly: dynamics to disease.

Lisa M Godsel1, Ryan P Hobbs, Kathleen J Green

  • 1Department of Pathology, Northwestern University Feinberg School of Medicine, 303 E. Chicago Avenue, Chicago IL 60611, USA. l-godsel@northwestern.edu

Trends in Cell Biology
|December 18, 2007
PubMed
Summary
This summary is machine-generated.

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Intermediate filaments (IFs) are dynamic cytoskeletal proteins. This review explores their assembly, transport, and interactions, highlighting how defects impact cellular stress protection.

Area of Science:

  • Cell Biology
  • Biochemistry
  • Biophysics

Background:

  • Intermediate filament (IF) proteins form a diverse gene family crucial in vertebrate tissues.
  • Despite their 'toughest' fiber reputation, IFs exhibit dynamic and regulated behavior in cultured cells.

Purpose of the Study:

  • To review the diverse assembly behaviors of intermediate filament proteins.
  • To explore the mechanisms of IF precursor delivery and interaction with cellular components.
  • To discuss the implications of IF assembly defects on cellular functions.

Main Methods:

  • Literature review of studies on intermediate filament protein assembly and dynamics.
  • Analysis of mechanisms involving protein precursors, motor proteins, and IF-associated proteins (IFAPs).

Related Experiment Videos

  • Examination of the impact of mutations on IF network formation and function.

    • Main Results:

    • IF proteins assemble into oligomeric precursors, potentially delivered via microtubule and actomyosin systems.
    • IF-associated proteins (IFAPs) significantly influence IF dynamics and network properties.
    • Mutations affecting IF assembly or IF-IFAP interactions compromise IFs' protective roles against environmental stress.

    Conclusions:

    • Intermediate filaments are highly regulated cytoskeletal elements with complex assembly and transport mechanisms.
    • IF-IFAP interactions are critical for establishing functional cellular networks.
    • Defects in IF assembly or network formation underlie various in vivo functional impairments, particularly in stress response.