Related Experiment Video
Updated: Jul 9, 2026

10:10
Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
Published on: February 15, 2022
Ocular hypertension associated with ocular sarcoidosis
Salman Mirza1, Tariq Saeed, Philip I Murray
1Birmingham and Midland Eye Centre, Birmingham, UK.
Ocular Immunology and Inflammation
|December 19, 2007
Summary
Ocular sarcoidosis can lead to severe bilateral ocular hypertension, a condition where eye pressure is significantly elevated in both eyes. This finding highlights the importance of monitoring intraocular pressure in patients with ocular sarcoidosis.
Area of Science:
- Ophthalmology
- Rheumatology
- Immunology
Background:
- Sarcoidosis is a multisystem inflammatory disease.
- Ocular involvement is common in sarcoidosis, manifesting as uveitis.
- Ocular sarcoidosis requires careful management to prevent vision loss.
Observation:
- This study reviewed cases of sarcoidosis-related uveitis.
- Five patients with confirmed ocular sarcoidosis were identified.
- All identified patients presented with bilateral ocular hypertension, defined as intraocular pressure exceeding 40 mmHg in each eye.
Findings:
- A significant association exists between ocular sarcoidosis and bilateral ocular hypertension.
- Elevated intraocular pressure (IOP) is a critical finding in these patients.
- The severity of IOP elevation suggests a direct impact of sarcoid inflammation on ocular structures.
Implications:
- Ophthalmologists and rheumatologists should consider ocular sarcoidosis in patients presenting with unexplained bilateral ocular hypertension.
- Early detection and management of ocular sarcoidosis-related hypertension are crucial for preventing glaucomatous damage.
- Awareness of this association can lead to timely intervention and improved patient outcomes.
Related Concept Videos
Glaucoma: Overview
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Accessory Structures of the Eye
Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...
Ophthalmic Drug Delivery Systems
Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
Photoreceptors and Visual Pathways
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...

