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Exploratory behavior in mice selectively bred for developmental differences in aggressive behavior.

Kathryn E Hood1, Karen S Quigley

  • 1Pennsylvania State University, University Park, PA 16802, USA. ig4@psu.edu

Developmental Psychobiology
|December 19, 2007
PubMed
Summary
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Aggressive behavior in mice is linked to altered developmental timing, influencing exploratory behaviors. High-aggressive mice show mature exploration patterns earlier, suggesting developmental shifts drive behavioral differences.

Area of Science:

  • Behavioral Neuroscience
  • Developmental Psychology
  • Animal Behavior

Background:

  • Selective breeding in mice (Cairns lines) created distinct lines based on aggressive behavior: high-aggressive (900), low-aggressive (100), and control (500).
  • R. B. Cairns proposed that differences in aggressive behavior stem from altered developmental timing.

Purpose of the Study:

  • To assess the development and expression of exploratory behavior in selectively bred aggressive mouse lines.
  • To investigate the relationship between developmental timing, aggression, and exploratory patterns.

Main Methods:

  • Four exploratory behavior paradigms were used across different age groups of mice.
  • Behavioral assessments included novel arena exploration, light-dark box, and neohypophagia tests.

Related Experiment Videos

Main Results:

  • Older male mice generally showed increased exploration in novel environments compared to younger males.
  • High-aggressive (900) line males exhibited accelerated development of mature exploratory behaviors.
  • The 900 line displayed behavioral inhibition in novel settings, contrasting with faster exploration of novel objects.

Conclusions:

  • The findings support the hypothesis that altered developmental timing influences aggressive and exploratory behaviors.
  • Behavioral inhibition in novel settings and accelerated exploration in the high-aggressive line suggest complex developmental shifts.
  • Exploratory behavior patterns in the 900 line align with approach-withdrawal theories in novel environments.