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Angiogenesis in cutaneous lesions of leprosy: implications for treatment
Sulochana S Bhandarkar1, Cynthia Cohen, Maria Kuruvila
1Department of Dermatology, Emory University School of Medicine, WMB 5309, 1639 Pierce Dr, Atlanta, GA 30322, USA.
Objective:
To examine the potential role of angiogenesis in leprosy.
Design:
Immunohistochemical analysis of leprosy lesions.
Setting:
Department of Dermatology, Venereology, and Leprology, Kasturba Medical College; Division of Dermatology, University of California at Los Angeles; and Departments of Dermatology and Pathology, Emory University.
Patients:
Thirty-two cutaneous lesions that represented the spectrum of leprosy were obtained from 32 patients.
Main Outcome Measure:
CD31 microvessel counts.
Results:
The mean CD31 microvessel count in borderline tuberculoid, midborderline, and lepromatous leprosy lesions was significantly higher than in indeterminate leprosy lesions.
Conclusions:
Increased bacterial load is associated with increased angiogenesis. Angiogenesis inhibitors may be of benefit in the treatment of leprosy.
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