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Related Experiment Videos

Evoked brain responses are generated by feedback loops.

Marta I Garrido1, James M Kilner, Stefan J Kiebel

  • 1Wellcome Trust Centre for Neuroimaging, University College London, London WC1N 3BG, United Kingdom. m.garrido@fil.ion.ucl.ac.uk

Proceedings of the National Academy of Sciences of the United States of America
|December 19, 2007
PubMed
Summary
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Brain responses involve recurrent network dynamics. Backward connections are essential for generating late components of event-related potentials, crucial for perceptual inference.

Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Cognitive Neuroscience

Background:

  • Neuronal responses to stimuli exhibit early (exogenous) and late (endogenous) components.
  • Early components are linked to bottom-up sensory processing.
  • Late components are hypothesized to involve top-down, recurrent cortical dynamics.

Purpose of the Study:

  • To investigate the role of recurrent dynamics and backward connections in generating evoked brain responses.
  • To determine if backward connections mediate late components of event-related responses.

Main Methods:

  • Utilized dynamic causal modeling (DCM) of mismatch responses from an oddball paradigm.
  • Assessed model evidence with and without backward connections across peristimulus time.

Related Experiment Videos

  • Quantified the contribution of backward connections to evoked responses and source activity.

    • Main Results:

    • Backward connections are necessary to explain the late components of evoked brain responses.
    • The contribution of backward connections to evoked responses and source activity was quantified over time.
    • Recurrent dynamics in cortical networks generate evoked brain responses.

    Conclusions:

    • Late components of event-related responses are mediated by backward connections.
    • Backward connections are critical for recurrent interactions within cortical hierarchies.
    • These findings support theories of perceptual inference and learning.