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Peripheral sensory nerve regeneration with biodegradable materials and neurotropic factor

Arden K Hegtvedt1, John R Zuniga, Erick M Rath

  • 1Department of Oral and Maxillofacial Surgery, The Ohio State University, 305 W. 12th Avenue, Columbus, OH 43218, USA.

Oral and Maxillofacial Surgery Clinics of North America
|December 20, 2007
PubMed
Abstract

No abstract available in PubMed .

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

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