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Updated: Jul 9, 2026

Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
Published on: July 31, 2016
Perioperative management of the patient with hematologic disorders
Guillermo E Chacon1, Carlos M Ugalde
1Section of Oral and Maxillofacial Surgery, Anesthesiology, and Oral and Maxillofacial Pathology, The Ohio State University Medical Center, 305 West 12th Avenue, Box 182357, Columbus, OH 43218-2357, USA. chacon.4@osu.edu
Abstract:
Bleeding at the time of surgery has the potential to become a serious complication. Careful patient assessment and review of history are of the utmost importance if this situation is to be avoided on the operating table. Unfortunately, many patients, particularly younger individuals with little to no previous exposure to surgery, are unaware of underlying bleeding disorders that they may have. Understanding the basic pathophysiology and management of these conditions becomes critical for the treating surgeon. For patients who have known conditions, close interconsultation with the treating hematologists and careful observation of preoperative, intraoperative, and postoperative established protocols reduces the risk of complications for patients and makes the possibility of success a reality for these individuals.
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