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Bisphosphonates and bisphosphonate induced osteonecrosis
1Division of Oral and Maxillofacial Surgery, University of Miller Miami School of Medicine, 9380 SW 150th Street, Miami, FL 33157, USA. ysawatari@med.miami.edu
Oral and Maxillofacial Surgery Clinics of North America
|December 20, 2007
Summary
Bisphosphonate-induced osteonecrosis of the jaws (ONJ) is a dental complication. Risk factors include drug potency, administration route, and duration, but ONJ is often preventable and manageable.
Area of Science:
- Dental Medicine
- Pharmacology
- Oncology
Background:
- Bisphosphonate-induced osteonecrosis of the jaws (ONJ) is a recognized complication.
- Nitrogen-containing bisphosphonates are associated with ONJ risk.
- Risk is influenced by administration route, drug potency, and duration of use.
Purpose of the Study:
- To define the correct terminology for bisphosphonate-related jaw osteonecrosis.
- To outline risk factors and management strategies for ONJ.
- To emphasize the importance of preventative measures and early intervention.
Main Methods:
- Review of clinical data and literature on bisphosphonate-induced ONJ.
- Analysis of risk factors associated with intravenous and oral bisphosphonates.
- Evaluation of management strategies including drug holidays and débridement.
Main Results:
- Intravenous bisphosphonate-ONJ is often permanent but preventable or manageable.
- Oral bisphosphonate-ONJ prevention involves risk assessment based on duration and C-terminal telopeptide levels.
- Most oral ONJ cases resolve with drug holidays or débridement.
Conclusions:
- Bisphosphonate-induced ONJ is a significant clinical concern for dental practitioners.
- Understanding risk factors and implementing preventative strategies are crucial.
- Effective management strategies exist for both intravenous and oral bisphosphonate-related ONJ.
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