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Related Experiment Video

Updated: Jul 9, 2026

Murine Full-thickness Skin Transplantation

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Published on: January 2, 2017

Posttransplantation conversion to sirolimus-based immunosuppression: a single center experience.

L T Santamaria Saber¹, M Y Ikeda, J M Almeida

¹Renal Transplant Unit, Hospital das Clinicas, University of São Paulo-Ribeirão Preto, São Paulo, Brazil.

Transplantation Proceedings

|December 20, 2007

Summary

Sirolimus (SRL) improves kidney transplant function after conversion, particularly for chronic allograft nephropathy (CAN). However, reducing immunosuppression is crucial to mitigate side effects like infections and myelotoxicity.

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Surgical Angiogenesis in Porcine Tibial Allotransplantation: A New Large Animal Bone Vascularized Composite Allotransplantation Model

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Published on: August 13, 2017

Area of Science:

Nephrology
Transplantation Immunology
Pharmacology

Background:

Sirolimus (SRL) is an emerging option for kidney transplant recipients, especially those with chronic allograft nephropathy (CAN).
Calcineurin inhibitor (CNI) nephrotoxicity and CAN are primary reasons for switching immunosuppressive therapy.

Purpose of the Study:

To evaluate the safety and efficacy of sirolimus (SRL) conversion in kidney transplant recipients.
To assess the impact of SRL on renal function and identify associated adverse events.

Main Methods:

A cohort of 103 kidney recipients underwent conversion to SRL-based immunosuppression.
Renal function was monitored by proteinuria and inverse serum creatinine pre- and post-conversion.
Adverse events and reasons for SRL discontinuation were recorded.

Main Results:

Significant improvement in renal function was observed at 1 month post-conversion, with stabilization thereafter.
Common side effects included anemia and leukopenia with SRL/mycophenolate mofetil (MMF).
Infections and graft loss due to CAN were significant concerns.

Conclusions:

Sirolimus (SRL) offers a viable therapeutic option for kidney transplant recipients, particularly those with chronic allograft nephropathy (CAN).
Reducing the intensity of associated immunosuppression is recommended to minimize adverse events, especially infections.
Careful monitoring for side effects is essential during SRL therapy.