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Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
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Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

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Leukemia cutis.

Jeong Hee Cho-Vega1, L Jeffrey Medeiros, Victor G Prieto

  • 1Department of Pathology, The Methodist Hospital, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

American Journal of Clinical Pathology
|December 20, 2007
PubMed
Summary
This summary is machine-generated.

Leukemia cutis (LC) presents as skin lesions in leukemia patients, sometimes preceding diagnosis. Immunophenotyping of skin biopsies aids LC diagnosis and understanding leukemic cell skin tropism.

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Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
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Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia

Published on: September 18, 2013

Area of Science:

  • Dermatology
  • Hematology
  • Oncology

Background:

  • Leukemia cutis (LC) refers to skin manifestations of leukemia, often mimicking other dermatoses.
  • Skin involvement can precede systemic leukemia diagnosis, making early detection crucial.
  • The pathogenesis of LC, particularly leukemic cell skin tropism, requires further elucidation.

Purpose of the Study:

  • To review current literature and recent advances in Leukemia cutis.
  • To emphasize the role of immunohistochemical assessment in LC diagnosis.
  • To explore potential mechanisms underlying leukemic cell skin tropism.

Main Methods:

  • Literature review of Leukemia cutis.
  • Focus on immunohistochemical assessment of skin biopsy specimens.
  • Discussion of molecular mechanisms, including chemokine receptors and adhesion molecules.

Main Results:

  • Immunophenotyping of skin biopsies is highly valuable for diagnosing LC.
  • Cutaneous manifestations of LC are diverse and can be diagnostically challenging.
  • Chemokine receptors and adhesion molecules are implicated in leukemic cell skin tropism.

Conclusions:

  • Skin biopsy with immunophenotyping is critical for diagnosing LC, especially when it precedes systemic leukemia.
  • Further research into the molecular mechanisms of skin tropism is needed for a comprehensive understanding of LC pathogenesis.